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Helen McGuire was a normal housewife who was recently divorced and had a young daughter named Emma.

Helen's brother, Commander Frank McGuire was the Head of a Naval division up until his death in a standoff between members of a Mexican drug gang and the Los Angeles Police Department, prompting the Office of Special Projects led by G. Callen to be called in to investigate on orders of NCIS Director Leon Vance.

It was revealed that Emma had been kidnapped by the same drug cartel which was led by her father and Helen's ex-husband, Luis.

After the case was solved, Helen had an emotional reunion with her daughter.